Development of a novel azaspirane that targets the Janus Kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo

Development of a novel azaspirane that targets the Janus Kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates genes involved in cell growth, proliferation, and survival, and given its association with many types of cancers, it has recently emerged as a promising target for therapy. In this work, we present th...

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Bibliographic Details
Main Authors: Mohan, C., Bharathkumar, H., Bulusu, K., Pandey, V., Rangappa, S., Fuchs, J., Shanmugam, M., Dai, X., Li, F., Deivasigamani, A., Hui, K., Kumar, Alan Prem, Lobie, P., Bender, A., Basappa, Sethi, G., Rangappa, K.
Format: Journal Article
Published: American Society for Biochemistry and Molecular Biology Inc. 2014
Online Access:http://hdl.handle.net/20.500.11937/27821

Internet

http://hdl.handle.net/20.500.11937/27821

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