Cross-linked human serum albumin dimer has the potential for use as a plasma-retaining agent for the fatty acid-conjugated antidiabetic drugs
Objectives The half-life of fatty acid-conjugated antidiabetic drugs are prolonged through binding to albumin, but this may not occur in diabetic patients with nephropathy complicated with hypoalbuminemia. We previously showed that human serum albumin (HSA) dimerized at the protein's Cys34 by 1...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Blackwell Publishing Ltd
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/27086 |