Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations
The amino acid l-leucine has been demonstrated to act as a lubricant and improve the dispersibility of otherwise cohesive fine particles. It was hypothesized that optimum surface l-leucine concentration is necessary to achieve optimal surface and bulk powder properties. Polyvinylpyrrolidone was spra...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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2015
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/2700 |
| _version_ | 1848744024975867904 |
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| author | Mangal, S. Meiser, F. Tan, G. Gengenbach, T. Denman, J. Rowles, Matthew Larson, I. Morton, D. |
| author_facet | Mangal, S. Meiser, F. Tan, G. Gengenbach, T. Denman, J. Rowles, Matthew Larson, I. Morton, D. |
| author_sort | Mangal, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The amino acid l-leucine has been demonstrated to act as a lubricant and improve the dispersibility of otherwise cohesive fine particles. It was hypothesized that optimum surface l-leucine concentration is necessary to achieve optimal surface and bulk powder properties. Polyvinylpyrrolidone was spray dried with different concentration of l-leucine and the change in surface composition of the formulations was determined using X-ray photoelectron spectroscopy (XPS) and time of flight-secondary ion mass spectrometry (ToF-SIMS). The formulations were also subjected to powder X-ray diffraction analysis in order to understand the relationship between surface concentration and solid-state properties of l-leucine. In addition, the morphology, surface energy and bulk cohesion of spray dried formulations were also assessed to understand the relation between surface l-leucine concentration and surface and bulk properties. The surface concentration of l-leucine increased with higher feed concentrations and plateaued at about 10% l-leucine. Higher surface l-leucine concentration also resulted in the formation of larger l-leucine crystals and not much change in crystal size was noted above 10% l-leucine. A change in surface morphology of particles from spherical to increasingly corrugated was also observed with increasing surface l-leucine concentration. Specific collapsed/folded over particles were only seen in formulations with 10% or higher l-leucine feed concentration suggesting a change in particle surface formation process. In addition, bulk cohesion also reduced and approached a minimum with 10% l-leucine concentration. Thus, the surface concentration of l-leucine governs particle formation and optimum surface l-leucine concentration results in optimum surface and bulk powder properties. |
| first_indexed | 2025-11-14T05:54:54Z |
| format | Journal Article |
| id | curtin-20.500.11937-2700 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T05:54:54Z |
| publishDate | 2015 |
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| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-27002017-09-13T14:33:01Z Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations Mangal, S. Meiser, F. Tan, G. Gengenbach, T. Denman, J. Rowles, Matthew Larson, I. Morton, D. - Inter-particle cohesion - Spray drying L-Leucine - Polyvinylpyrrolidone - Surface mapping The amino acid l-leucine has been demonstrated to act as a lubricant and improve the dispersibility of otherwise cohesive fine particles. It was hypothesized that optimum surface l-leucine concentration is necessary to achieve optimal surface and bulk powder properties. Polyvinylpyrrolidone was spray dried with different concentration of l-leucine and the change in surface composition of the formulations was determined using X-ray photoelectron spectroscopy (XPS) and time of flight-secondary ion mass spectrometry (ToF-SIMS). The formulations were also subjected to powder X-ray diffraction analysis in order to understand the relationship between surface concentration and solid-state properties of l-leucine. In addition, the morphology, surface energy and bulk cohesion of spray dried formulations were also assessed to understand the relation between surface l-leucine concentration and surface and bulk properties. The surface concentration of l-leucine increased with higher feed concentrations and plateaued at about 10% l-leucine. Higher surface l-leucine concentration also resulted in the formation of larger l-leucine crystals and not much change in crystal size was noted above 10% l-leucine. A change in surface morphology of particles from spherical to increasingly corrugated was also observed with increasing surface l-leucine concentration. Specific collapsed/folded over particles were only seen in formulations with 10% or higher l-leucine feed concentration suggesting a change in particle surface formation process. In addition, bulk cohesion also reduced and approached a minimum with 10% l-leucine concentration. Thus, the surface concentration of l-leucine governs particle formation and optimum surface l-leucine concentration results in optimum surface and bulk powder properties. 2015 Journal Article http://hdl.handle.net/20.500.11937/2700 10.1016/j.ejpb.2015.04.035 restricted |
| spellingShingle | - Inter-particle cohesion - Spray drying L-Leucine - Polyvinylpyrrolidone - Surface mapping Mangal, S. Meiser, F. Tan, G. Gengenbach, T. Denman, J. Rowles, Matthew Larson, I. Morton, D. Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations |
| title | Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations |
| title_full | Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations |
| title_fullStr | Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations |
| title_full_unstemmed | Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations |
| title_short | Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations |
| title_sort | relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations |
| topic | - Inter-particle cohesion - Spray drying L-Leucine - Polyvinylpyrrolidone - Surface mapping |
| url | http://hdl.handle.net/20.500.11937/2700 |