A double mutation of MBP83-99 peptide induces IL-4 responses and antagonizes IFN-? responses

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A double mutation of MBP83-99 peptide induces IL-4 responses and antagonizes IFN-? responses

A number of treatment options are available to multiple sclerosis patients, however this needs to be improved. Herein, we designed and synthesized a number of peptides by mutating principal TCR contact residues based on MBP83-99 peptide epitope. Immunization of SJL/J mice with MBP83-99 and mutant [A...

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Bibliographic Details
Main Authors:	Katsara, M., Yuriev, E., Ramsland, Paul, Deraos, G., Tselios, T., Matsoukas, J., Apostolopoulos, V.
Format:	Journal Article
Published:	Elsevier BV 2008
Online Access:	http://hdl.handle.net/20.500.11937/26942

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