A double mutation of MBP83-99 peptide induces IL-4 responses and antagonizes IFN-? responses
A number of treatment options are available to multiple sclerosis patients, however this needs to be improved. Herein, we designed and synthesized a number of peptides by mutating principal TCR contact residues based on MBP83-99 peptide epitope. Immunization of SJL/J mice with MBP83-99 and mutant [A...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier BV
2008
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| Online Access: | http://hdl.handle.net/20.500.11937/26942 |