Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity

Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity

Background: A strategy for preventing cisplatin nephrotoxicity due to enhanced oxidative stress and inflammatory response is highly desirable. Thioredoxin-1 (Trx), an endogenous redox-active protein, has a short retention time in the blood. A long acting form of Trx, human serum albumin-Trx (HSA-Trx...

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Bibliographic Details
Main Authors: Kodama, A., Watanabe, H., Tanaka, R., Kondo, M., Chuang, Victor, Wu, Q., Endo, M., Ishima, Y., Fukagawa, M., Otagiri, M., Maruyama, T.
Format: Journal Article
Published: Elsevier BV 2014
Subjects:
Thioredoxin
Oxidative stress
Acute kidney injury
Cisplatin nephrotoxicity
Fusion protein
Inflammation
Online Access:http://hdl.handle.net/20.500.11937/26865

Internet

http://hdl.handle.net/20.500.11937/26865

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