The synthesis and biological evaluation of novel analogues of isocryptolepine

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The synthesis and biological evaluation of novel analogues of isocryptolepine

This thesis investigates the potential of the alkaloid isocryptolepine 16 as a lead compound in antimalarial drug development. Fifteen derivatives of the parent alkaloid were prepared and fully characterised, twelve of which were novel compounds. A select group of compounds were subsequently evaluat...

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Bibliographic Details
Main Author:	Whittell, Louise Renee'
Format:	Thesis
Language:	English
Published:	Curtin University 2011
Subjects:	lead compound halogenated derivatives Molina Method antimalarial activity antimalarial drug development selective electrophilic aromatic substitution alkaloid isocryptolepine 16 cytotoxicity Jonckers Method synthetic methodologies
Online Access:	http://hdl.handle.net/20.500.11937/2558

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