Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats

QR Code

Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats

The aim is to investigate the influence of the antidiabetic drug gliclazide on the ileal permeation of the semisynthetic bile acid, MKC, in tissues from healthy and diabetic rats. Sixteen Wistar rats (350 +/- 50 g) were randomly allocated into four groups (4 rats per group, 8 chambers per rat, i.e.,...

Full description

Bibliographic Details
Main Authors:	Al-Salami, Hani, Butt, G., Tucker, I., Fawcett, P., Golocorbin-Kon, S., Mikov, I., Mikov, M.
Format:	Journal Article
Published:	Springer France 2009
Subjects:	permeation Mrp3 transporters gliclazide diabetes bile acid
Online Access:	http://hdl.handle.net/20.500.11937/25466

Similar Items

Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: A Characterization Study
by: Mooranian, Armin, et al.
Published: (2014)

Stability and Release Kinetics of an Advanced Gliclazide-Cholic Acid Formulation: The Use of Artificial-Cell Microencapsulation in Slow Release Targeted Oral Delivery of Antidiabetics
by: Mooranian, Armin, et al.
Published: (2014)

Influence of the semisynthetic bile acid MKC on the ileal permeation of gliclazide in vitro in healthy and diabetic rats treated with probiotics
by: Al-Salami, Hani, et al.
Published: (2008)

Diabetes and hypertension increase the placental and transcellular permeation of the lipophilic drug diazepam in pregnant women
by: Lalic-Popovic, M., et al.
Published: (2013)

Potentials and Limitations of Bile Acids in Type 2 Diabetes Mellitus: Applications of Microencapsulation as a Novel Oral Delivery System
by: Negrulj, Rebecca, et al.
Published: (2013)

Probiotics decreased the bioavailability of the bile acid analog, monoketocholic acid, when coadministered with gliclazide, in healthy but not diabetic rats
by: Al-Salami, Hani, et al.
Published: (2012)

Application of bile acids in drug formulation and delivery
by: Stojancevic, M., et al.
Published: (2014)

Probiotic pre-treatment reduces gliclazide permeation (ex vivo) in healthy rats but increases it in diabetic rats to the level seen in untreated healthy rats
by: Al-Salami, Hani, et al.
Published: (2008)

THE EFFECT OF BILE ACID SALT SODIUM 3ALPHA, 7ALPHA-DIHYDROXY-12-KETO-5BETA-CHOLANATE (MKC) AND PROBIOTIC PRETREATMENT ON GLICLAZIDE PERMEATION IN ILEAL TISSUES FROM HEALTHY AND DIABETIC RATS
by: Mikov, M., et al.
Published: (2014)

Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches.
by: Elnashar, Magdy, et al.
Published: (2020)

ERP-based introduction of MRP for process manufacturers using the example of Gerlinger Klebebandwerke GmbH & Co. KG
by: Gerlinger, Friedrich
Published: (2011)

An optimized probucol microencapsulated formulation integrating a secondary bile acid (deoxycholic acid) as a permeation enhancer
by: Mooranian, Armin, et al.
Published: (2014)

An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques
by: Mooranian, Armin, et al.
Published: (2019)

Investigating the bile acid mediated control of Clostridioides difficile infection
by: von Emloh, Louise
Published: (2024)

Correlation between in vitro tests for blood brain barrier penetration with in vivo gliclazide penetration
by: Lalic-Popovic, M., et al.
Published: (2013)

Deoxycholic Acid as a Modifier of the Permeation of Gliclazide through the Blood Brain Barrier of a Rat
by: Lalic-Popovic, M., et al.
Published: (2013)

Potential Applications of Gliclazide in Treating Type 1 Diabetes Mellitus: Formulation with Bile Acids and Probiotics
by: Mikov, M., et al.
Published: (2017)

Inhibition of the lysophosphatidylinositol transporter abcc1 reduces prostate cancer cell growth and sensitizes to chemotherapy
by: Emmanouilidi, Aikaterini, et al.
Published: (2020)

Data supporting development and validation of liquid chromatography tandem mass spectrometry method for the quantitative determination of bile acids in feces
by: Shafaei, A., et al.
Published: (2021)

Species Classification and Molecular Studies of Bile Salt Hydrolase (BSH) Gene in Bifidobacterium Spp
by: Mustafa, Shuhaimi
Published: (2003)

Pharmacokinetic and Drug Absorption Profiles of the Anti-Hyperglycaemic Agent Gliclazide in Oral Tissue-Targeted Microcapsules in Rats
by: Jovic, Jelena, et al.
Published: (2020)

High-Loading Dose of Microencapsulated Gliclazide Formulation Exerted a Hypoglycaemic Effect on Type 1 Diabetic Rats and Incorporation of a Primary Deconjugated Bile Acid, Diminished the Hypoglycaemic Antidiabetic Effect
by: Golocorbin-Kon, S., et al.
Published: (2017)

Probucol Release from Novel Multicompartmental Microcapsules for the Oral Targeted Delivery in Type 2 Diabetes
by: Mooranian, Armin, et al.
Published: (2014)

Diabetes development increased concentrations of the conjugated bile acid, taurocholic acid in serum, while treatment with microencapsulated-taurocholic acid exerted no hypoglycaemic effects
by: Mathavan, S., et al.
Published: (2017)

The impact of the level of the intestinal short chain Fatty acids in inflammatory bowel disease patients versus healthy subjects.
by: Faujan, Nur Huda, et al.
Published: (2010)

Probiotics applications in autoimmune diseases
by: Al-Salami, Hani, et al.
Published: (2012)

Microstructure control of oxygen permeation membranes with templated microchannels
by: Shao, Xin, et al.
Published: (2014)

Analysing the Skin Barrier from Down Under
by: Grice, J., et al.
Published: (2013)

The Influence of Intestinal Tract and Probiotics on the Fate of Orally Administered Drugs
by: Stojancevic, M., et al.
Published: (2013)

Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol
by: Mooranian, Armin, et al.
Published: (2014)

The role of Proline-Rich Homeodomain protein PRH/HHEX in cholangiocarcinoma
by: Ghouth, Nahlah
Published: (2024)

Dried Blood Spot: Utilizing Dry Blood For Pharmacokinetic Investigations—An Old Method with Great Future for Therapeutic Drug Monitoring
by: Maksimovic, V., et al.
Published: (2017)

Dried blood spot: Utilising dry blood for pharmacokinetic investigations - An old method with great future for therapeutic drug monitoring
by: Golocorbin-Kon, S., et al.
Published: (2018)

Extraction and quantitative determination of bile acids in feces
by: Shafaei, A., et al.
Published: (2021)

Novel chenodeoxycholic acid-sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. An in vitro study
by: Mooranian, A., et al.
Published: (2015)

Strength and permeation properties of slag blended fly ash based geopolymer concrete
by: Deb, Partha, et al.
Published: (2013)

Improvement of oxygen permeation through microchanneled ceramic membranes
by: Shao, Xin, et al.
Published: (2014)

La0.7Sr0.3FeO3-α perovskite hollow fiber membranes for oxygen permeationand methane conversion
by: Tan, X., et al.
Published: (2012)

Cationic supramolecular hydrogels for overcoming the skin barrier in drug delivery
by: Limon, David, et al.
Published: (2017)

Effects of polymerization conditions on the properties of poly(furfuryl alcohol) composite membranes
by: He, L., et al.
Published: (2012)

Cannot write session to /tmp/vufind_sessions/sess_pqfcms27aqup3br1i2geqifjqo