Predicting the parasite killing effect of artemisinin combination therapy in a murine malaria model

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Predicting the parasite killing effect of artemisinin combination therapy in a murine malaria model

Objectives: To develop a mechanism-based model that describes the time course of the malaria parasite in infected mice receiving a combination therapy regimen of dihydroartemisinin and piperaquine. Methods: Total parasite density–time data from Swiss mice inoculated with Plasmodium berghei were used...

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Bibliographic Details
Main Authors:	Patel, K., Batty, Kevin, Moore, Brioni, Gibbons, Peter, Kirkpatrick, C.
Format:	Journal Article
Published:	Oxford University Press 2014
Subjects:	piperaquine mechanism-based modelling population pharmacodynamics dihydroartemisinin Plasmodium berghei
Online Access:	http://hdl.handle.net/20.500.11937/24949

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