Low-Dose Sublingual Ketamine Does Not Modulate Experimentally Induced Mechanical Hyperalgesia in Healthy Subjects

QR Code

Low-Dose Sublingual Ketamine Does Not Modulate Experimentally Induced Mechanical Hyperalgesia in Healthy Subjects

Objective: Musculoskeletal pain has been associated with N-methyl-d-aspartate (NMDA) receptor-mediated mechanisms. This randomized controlled trial (RCT) investigated the effect of the NMDA receptor antagonist ketamine (25 mg sublingually) on modulating experimental muscle pain. Design: Two groups (...

Full description

Bibliographic Details
Main Authors:	Slater, Helen, Graven-Neilsen, T., Wright, Anthony, Schug, S.
Format:	Journal Article
Published:	Wiley-Blackwell Publishing, Inc 2012
Online Access:	http://hdl.handle.net/20.500.11937/24474

Similar Items

Sensory responses to mechanically and chemically induced tendon pain in healthy subjects
by: Slater, Helen, et al.
Published: (2011)

The absolute bioavailability of racemic ketamine from a novel sublingual formulation
by: Rolan, P., et al.
Published: (2014)

Glutamate and capsaicin-induced pain, hyperalgesia and modulatory interactions in human tendon tissue
by: Gibson, William, et al.
Published: (2009)

A Phase I Pharmacokinetic and Bioavailability Study of a Sublingual Fentanyl Wafer in Healthy Volunteers
by: Lim, Stephen, et al.
Published: (2012)

Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold
by: Moss, Penny, et al.
Published: (2016)

Comparison of effectiveness and safety of ketamine with midazolam against higher dose of ketamine as procedural sedation for lumbar puncture in paediatric leukaemic patients
by: Faisal, Ahmed
Published: (2011)

Serum concentration of ketamine and antinociceptive effects of ketamine and ketamine-lidocaine infusions in conscious dogs
by: Kaka, Ubedullah, et al.
Published: (2016)

Comparison of different subanaesthetic ketamine doses on perioperative opioid consumption in major gynaecological surgery
by: Kamaruzaman, Puteri Nadia
Published: (2020)

Effects of a manual therapy technique in experimental lateral epicondylalgia
by: Slater, Helen, et al.
Published: (2005)

In vitro and in vivo evaluation of a sublingual fentanyl wafer formulation
by: Lim, S, et al.
Published: (2013)

Comparison of the pre-emptive analgesia of low dose intravenous ketamine in combination with intravenous parecoxib versus intravenous ketamine alone on patients undergoing laparotomy under general anaesthesia
by: Ramli, Rabiatul Aida
Published: (2019)

Determination of an optimal dose of medetomidine-ketamine-buprenorphine for anaesthesia in the cape ground squirrel (Xerus inauris)
by: Joubert, K., et al.
Published: (2011)

Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients
by: Yeaman, F., et al.
Published: (2014)

Comparison of anaesthethic effect of ketamine-medetomidine, ketamine-medetomidine-morphine and ketamine-medetomidine-tramadol in red-eared sliders (Trachemys scripta elegans)
by: Zainal Ulum, Muhd Taqiyudin, et al.
Published: (2012)

Sensory and motor effects of experimental muscle pain in patients with lateral epicondylalgia and controls with delayed onset muscle soreness
by: Slater, Helen, et al.
Published: (2005)

Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects
by: Rabey, M., et al.
Published: (2014)

Development of a sublingualoral formulation of ketamine for use in neuropathic pain: Preliminary findings from a three-way randomized, crossover study
by: Chong, C., et al.
Published: (2009)

Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain
by: Abaei, Maryam, et al.
Published: (2016)

Cold Pain Threshold Identifies a Subgroup of Patients With Knee Osteoarthritis That Present With Multimodality Hyperalgesia and Elevated Pain Levels
by: Wright, Tony, et al.
Published: (2016)

Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma
by: Tabynov, Kairat, et al.
Published: (2025)

Vibration-Induced Afferent Activity Augments Delayed Onset Muscle Alloydynia
by: Ayles, S., et al.
Published: (2011)

Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat
by: Alsalem, Mohammad, et al.
Published: (2016)

Modulation of intraocular pressure by unilateral and forced unilateral nostril breathing in young healthy human subjects
by: Mohan, Satagopam Mitti, et al.
Published: (2001)

Fourteen days of etoricoxib 60 mg improves pain, hyperalgesia and physical function in individuals with knee osteoarthritis: a randomized controlled trial
by: Moss, P., et al.
Published: (2017)

Development and Evaluation of a Novel Buccal Dosage Form of Ketamine
by: Jahan, Fatima
Published: (2022)

Ketamine-xylazine/tiletamine-zolazepam prolonged anesthesia in Cynomolgus monkeys
by: Cheah, Pike See, et al.
Published: (2007)

Comparative histological evaluations of the sublingual salivary glands of EBN swiftlets (Aerodramus fuciphagus) in man-made houses and natural caves
by: Ibrahim, Muhammad Marwan, et al.
Published: (2017)

Patients With Knee Osteoarthritis Who Score Highly on the PainDETECT Questionnaire Present With Multi-modality Hyperalgesia, Increased Pain and Impaired Physical Function
by: Moss, P., et al.
Published: (2017)

Topical menthol identifies cold hyperalgesia in individuals with chronic pain from knee osteoarthritis
by: Moss, Penny
Published: (2013)

Increased pain from muscle fascia following eccentric exercise : animal and human findings
by: Gibson, William, et al.
Published: (2009)

Experimental deep tissue pain in wrist extensors--a model of lateral epicondylalgia
by: Slater, Helen, et al.
Published: (2003)

Clinical comparison of alfaxalone, ketamine and propofol following medetomidine and methadone in dogs
by: White, Kate L., et al.
Published: (2017)

Oral ketamine vs placebo in patients with cancer-related neuropathic pain
by: Fallon, Marie T., et al.
Published: (2018)

A Study On Ketamine Abusers In Georgetown, Kuala Lumpur And Johor Bahru
by: Suppiah, S. Batumalai
Published: (2016)

Etomidate versus ketamine for procedural sedation in paediatric Patients in the emergency department
by: Fatan, Ahmad Abdulbasitz Ahmad
Published: (2012)

The dose rate debate: Does the risk of fungicide resistance increase or decrease with dose?
by: Van den Bosch, F., et al.
Published: (2011)

Identification of mechano-sensitive C fibre sensitization and contribution to nerve injury-induced mechanical hyperalgesia
by: Hulse, Richard P.
Published: (2015)

Consumption of low doses of fat prevents the postprandial rise in chylomicron particle concentration and remnant accumulation in healthy normolipidaemic males
by: James, Anthony, et al.
Published: (2012)

Comparison of tiletamine-zolazepam and tiletamine-zolazepam-ketamine-xylazine administered intravenously in dogs
by: Chen, Hui Cheng, et al.
Published: (2005)

Analgesic efficacy of systemic ketamine and lignocaine for pre-emptive multimodal analgesia in dogs
by: Kaka, Ubedullah
Published: (2016)

Cannot write session to /tmp/vufind_sessions/sess_8tt8p65pqj280n0g7shaa3es3p