Differential patterns of methylation of the IFN promoter at CpG and non-CpG sites underlie differences in IFN gene expression between human neonatal and adult CD45RO- T-cells

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Differential patterns of methylation of the IFN promoter at CpG and non-CpG sites underlie differences in IFN gene expression between human neonatal and adult CD45RO- T-cells

IFN- is a potent pleiotropic Th1 cytokine, the production of which is tightly regulated during fetal development. Negative control of fetal/neonatal IFN- production is generally attributed to the Th1-antagonistic effect of mediators produced by the placenta, but evidence exists of additional and mor...

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Bibliographic Details
Main Authors:	White, Greg, Watt, P., Holt, B., Holt, P.
Format:	Journal Article
Published:	American Association of Immunologists 2002
Online Access:	http://www.jimmunol.org/cgi/content/abstract/168/6/2820 http://hdl.handle.net/20.500.11937/24398

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