Differential patterns of methylation of the IFN promoter at CpG and non-CpG sites underlie differences in IFN gene expression between human neonatal and adult CD45RO- T-cells
IFN- is a potent pleiotropic Th1 cytokine, the production of which is tightly regulated during fetal development. Negative control of fetal/neonatal IFN- production is generally attributed to the Th1-antagonistic effect of mediators produced by the placenta, but evidence exists of additional and mor...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
American Association of Immunologists
2002
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| Online Access: | http://www.jimmunol.org/cgi/content/abstract/168/6/2820 http://hdl.handle.net/20.500.11937/24398 |