In utero smoke exposure and role of maternal and infant glutathione S-transferase genes on airway responsiveness and lung function in infancy
Rationale: Xenobiotics in the maternal circulation are capable of crossing the placental barrier so a reduction in the mother and fetus's detoxification ability due to genetic variation in the glutathione S-transferases (GSTs) could expose the fetus to higher levels of toxins. Objectives: To in...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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American Thoracic Society
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/24274 |
| _version_ | 1848751382861971456 |
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| author | Murdzoska, J. Devadason, S. Khoo, S. Landau, L. Young, S. Goldblatt, J. Zhang, Guicheng Le Souëf, P. Hayden, C. |
| author_facet | Murdzoska, J. Devadason, S. Khoo, S. Landau, L. Young, S. Goldblatt, J. Zhang, Guicheng Le Souëf, P. Hayden, C. |
| author_sort | Murdzoska, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Rationale: Xenobiotics in the maternal circulation are capable of crossing the placental barrier so a reduction in the mother and fetus's detoxification ability due to genetic variation in the glutathione S-transferases (GSTs) could expose the fetus to higher levels of toxins. Objectives: To investigate the interactive effects of maternal smoking during pregnancy with maternal and infant GST genotypes on airway responsiveness (AR) and lung function in infancy. Methods: GSTT1, GSTP1 and GSTM1 were genotyped in infants and mothers, in utero smoke exposure was evaluated by questionnaire, AR was assessed by histamine challenge and V?maxFRC was measured using the rapid thoracoabdominal compression technique. We investigated the interactive effects of maternal smoking during pregnancy with maternal and infant GST genes on AR and lung function at 1, 6, and 12 months and longitudinally throughout the first year. Measurements and Main Results: Infant and/or maternal GSTT1 nonnull was associated with reduced AR at 12 months and throughout the first year and increased V?maxFRC at 6 months. Maternal GSTP1 Val/Val or Ile/Val was associated with increased V?maxFRC at 6 months. In infants exposed to in utero smoke, infant and/or maternal GSTT1 nonnull was associated with reduced AR at 1 month and throughout the first year and increased V?maxFRC throughout the first year. Maternal GSTP1 Val/Val or Ile/Val was associated with increased V?maxFRC at 6 months. Conclusions: GST genes may be especially important during fetal development as they may modify, through proficient detoxification, the effects of in utero maternal smoke exposure on AR and lung function in infants. |
| first_indexed | 2025-11-14T07:51:51Z |
| format | Journal Article |
| id | curtin-20.500.11937-24274 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:51:51Z |
| publishDate | 2010 |
| publisher | American Thoracic Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-242742017-09-13T15:09:36Z In utero smoke exposure and role of maternal and infant glutathione S-transferase genes on airway responsiveness and lung function in infancy Murdzoska, J. Devadason, S. Khoo, S. Landau, L. Young, S. Goldblatt, J. Zhang, Guicheng Le Souëf, P. Hayden, C. Rationale: Xenobiotics in the maternal circulation are capable of crossing the placental barrier so a reduction in the mother and fetus's detoxification ability due to genetic variation in the glutathione S-transferases (GSTs) could expose the fetus to higher levels of toxins. Objectives: To investigate the interactive effects of maternal smoking during pregnancy with maternal and infant GST genotypes on airway responsiveness (AR) and lung function in infancy. Methods: GSTT1, GSTP1 and GSTM1 were genotyped in infants and mothers, in utero smoke exposure was evaluated by questionnaire, AR was assessed by histamine challenge and V?maxFRC was measured using the rapid thoracoabdominal compression technique. We investigated the interactive effects of maternal smoking during pregnancy with maternal and infant GST genes on AR and lung function at 1, 6, and 12 months and longitudinally throughout the first year. Measurements and Main Results: Infant and/or maternal GSTT1 nonnull was associated with reduced AR at 12 months and throughout the first year and increased V?maxFRC at 6 months. Maternal GSTP1 Val/Val or Ile/Val was associated with increased V?maxFRC at 6 months. In infants exposed to in utero smoke, infant and/or maternal GSTT1 nonnull was associated with reduced AR at 1 month and throughout the first year and increased V?maxFRC throughout the first year. Maternal GSTP1 Val/Val or Ile/Val was associated with increased V?maxFRC at 6 months. Conclusions: GST genes may be especially important during fetal development as they may modify, through proficient detoxification, the effects of in utero maternal smoke exposure on AR and lung function in infants. 2010 Journal Article http://hdl.handle.net/20.500.11937/24274 10.1164/rccm.200812-1887OC American Thoracic Society restricted |
| spellingShingle | Murdzoska, J. Devadason, S. Khoo, S. Landau, L. Young, S. Goldblatt, J. Zhang, Guicheng Le Souëf, P. Hayden, C. In utero smoke exposure and role of maternal and infant glutathione S-transferase genes on airway responsiveness and lung function in infancy |
| title | In utero smoke exposure and role of maternal and infant glutathione S-transferase genes on airway responsiveness and lung function in infancy |
| title_full | In utero smoke exposure and role of maternal and infant glutathione S-transferase genes on airway responsiveness and lung function in infancy |
| title_fullStr | In utero smoke exposure and role of maternal and infant glutathione S-transferase genes on airway responsiveness and lung function in infancy |
| title_full_unstemmed | In utero smoke exposure and role of maternal and infant glutathione S-transferase genes on airway responsiveness and lung function in infancy |
| title_short | In utero smoke exposure and role of maternal and infant glutathione S-transferase genes on airway responsiveness and lung function in infancy |
| title_sort | in utero smoke exposure and role of maternal and infant glutathione s-transferase genes on airway responsiveness and lung function in infancy |
| url | http://hdl.handle.net/20.500.11937/24274 |