Synthesis, anti-thymidine phosphorylase activity and molecular docking of 5-thioxo-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ones

In our lead finding program, a series of 5-thioxo-[1,2,4]triazolo[1,5-a][1, 3,5]triazin-7-ones and their 5-thio-alkyl derivatives were designed and synthesized which contained different substituents at ortho-position of 2-phenyl ring attached to the fused ring structure. The preliminary pharmacologi...

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Bibliographic Details
Main Authors: Bera, H., Lee, M., Sun, L., Dolzhenko, Anton, Chui, W.
Format: Journal Article
Published: 2013
Online Access:http://hdl.handle.net/20.500.11937/24261