Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk

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Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk

Purpose: The aim of this investigation was to demonstrate that nonlinear mixed-effects population pharmacokinetic (PK) modeling can be used to evaluate data from studies of drug transport/excretion into human milk and hence to estimate infant exposure. Methods: A sparse dataset from a previously...

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Bibliographic Details
Main Authors:	Salman, S., Sy, S., Ilett, K., Page-Sharp, Madhu, Paech, M.
Format:	Journal Article
Published:	Springer-Verlag 2011
Subjects:	Population Pharmacokinetivs - Tramadol - O-desmethyltramadol - Milk - Infant Dose - Pediatrics
Online Access:	http://hdl.handle.net/20.500.11937/23482

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