Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk
Purpose: The aim of this investigation was to demonstrate that nonlinear mixed-effects population pharmacokinetic (PK) modeling can be used to evaluate data from studies of drug transport/excretion into human milk and hence to estimate infant exposure. Methods: A sparse dataset from a previously...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Springer-Verlag
2011
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/23482 |