Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation

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Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation

Signaling pathways for caspase-2-mediated apoptosis are poorly defined. This is partially due to a lack of a reproducible stimulus to trigger caspase-2 activation. We present the oligonucleotide Dz13, a DNA enzyme that cleaves c-Jun mRNA and is capable of inhibiting various model tumors in mice, whi...

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Bibliographic Details
Main Authors:	Dass, Crispin, Galloway, S., Choong, P.
Format:	Journal Article
Published:	Mary Ann Liebert inc 2010
Online Access:	http://hdl.handle.net/20.500.11937/23209

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