Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a

Background and Purpose: The spider-venom peptide PcTx1 is the most potent and selective inhibitor of acid-sensing ion channel (ASIC) 1a. It has centrally acting analgesic activity and is neuroprotective in rodent models of ischaemic stroke. Understanding the molecular details of the PcTx1: ASIC1a in...

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Bibliographic Details
Main Authors: Saez, N., Deplazes, Evelyne, Cristofori-Armstrong, B., Chassagnon, I., Lin, X., Mobli, M., Mark, A., Rash, L., King, G.
Format: Journal Article
Published: John Wiley & Sons 2015
Online Access:http://hdl.handle.net/20.500.11937/22975

Internet

http://hdl.handle.net/20.500.11937/22975

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