Waking up dormant tumor suppressor genes with zinc fingers, TALEs and the CRISPR/dCas9 system

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Waking up dormant tumor suppressor genes with zinc fingers, TALEs and the CRISPR/dCas9 system

The aberrant epigenetic silencing of tumor suppressor genes (TSGs) plays a major role during carcinogenesis and regaining these dormant functions by engineering of sequence-specific epigenome editing tools offers a unique opportunity for targeted therapies. However, effectively normalizing the expre...

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Bibliographic Details
Main Authors:	Garcia-Bloj, B., Moses, C., Sgro, A., Plani-Lam, J., Arooj, Mahira, Duffy, C., Thiruvengadam, S., Sorolla, A., Rashwan, R., Mancera, Ricardo, Leisewitz, A., Swift-Scanlan, T., Corvalan, A., Blancafort, P.
Format:	Journal Article
Published:	Impact Journals LLC 2016
Online Access:	http://hdl.handle.net/20.500.11937/22885

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