Waking up dormant tumor suppressor genes with zinc fingers, TALEs and the CRISPR/dCas9 system
The aberrant epigenetic silencing of tumor suppressor genes (TSGs) plays a major role during carcinogenesis and regaining these dormant functions by engineering of sequence-specific epigenome editing tools offers a unique opportunity for targeted therapies. However, effectively normalizing the expre...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Impact Journals LLC
2016
|
| Online Access: | http://hdl.handle.net/20.500.11937/22885 |