Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

Background: Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety of human cancer cells, including hepatocellular carcinoma (HCC). Thus, novel agents that can suppress STAT3 activatio...

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Bibliographic Details
Main Authors: Sethi, G., Chatterjee, S., Rajendran, P., Li, F., Shanmugam, M., Wong, K., Kumar, Alan Prem, Senapati, P., Behera, A., Hui, K., Basha, J., Natesh, N., Luk, J., Kundu, T.
Format: Journal Article
Published: BioMed Central Ltd. 2014
Subjects:
Acetylation
Apoptosis
Garcinol
STAT3
HCC
Online Access:http://hdl.handle.net/20.500.11937/21716

Internet

http://hdl.handle.net/20.500.11937/21716

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