The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line
The Wnt signalling pathway is involved in regulating cellular proliferation and differentiation, and aberrant activation has been described in several cancers including breast. Oestradiol up regulates Wnt pathway gene expression, and thereby activates the Wnt signalling pathway. We used the oestroge...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Lifescience Global
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/20199 |
| _version_ | 1848750240551665664 |
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| author | McLaren, S. Arfuso, Frank Zeps, N. Dharmarajan, Arunasalam |
| author_facet | McLaren, S. Arfuso, Frank Zeps, N. Dharmarajan, Arunasalam |
| author_sort | McLaren, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The Wnt signalling pathway is involved in regulating cellular proliferation and differentiation, and aberrant activation has been described in several cancers including breast. Oestradiol up regulates Wnt pathway gene expression, and thereby activates the Wnt signalling pathway. We used the oestrogen-responsive breast cancer cell line MCF-7 to examine the effects of secreted frizzled related protein 4 (sFRP-4) on oestradiol-induced growth, including gene expression of the Wnt signalling pathway genes Frizzled Receptor, Wnt-10b, and β-catenin. We demonstrate here that sFRP-4 inhibits oestradiol-induced cell growth in the MCF-7 cell line and also down regulates oestradiol-induced expression of selected Wnt signalling genes including β-catenin. We propose that sFRP-4 is a potent inhibitor of the Wnt signalling pathway and may negatively regulate oestradiol-mediated proliferation in human breast cancer cells. |
| first_indexed | 2025-11-14T07:33:41Z |
| format | Journal Article |
| id | curtin-20.500.11937-20199 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:33:41Z |
| publishDate | 2014 |
| publisher | Lifescience Global |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-201992017-09-13T13:49:38Z The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line McLaren, S. Arfuso, Frank Zeps, N. Dharmarajan, Arunasalam β-catenin cellular proliferation Wnt signalling oestradiol sFRP4 Breast cancer growth inhibition The Wnt signalling pathway is involved in regulating cellular proliferation and differentiation, and aberrant activation has been described in several cancers including breast. Oestradiol up regulates Wnt pathway gene expression, and thereby activates the Wnt signalling pathway. We used the oestrogen-responsive breast cancer cell line MCF-7 to examine the effects of secreted frizzled related protein 4 (sFRP-4) on oestradiol-induced growth, including gene expression of the Wnt signalling pathway genes Frizzled Receptor, Wnt-10b, and β-catenin. We demonstrate here that sFRP-4 inhibits oestradiol-induced cell growth in the MCF-7 cell line and also down regulates oestradiol-induced expression of selected Wnt signalling genes including β-catenin. We propose that sFRP-4 is a potent inhibitor of the Wnt signalling pathway and may negatively regulate oestradiol-mediated proliferation in human breast cancer cells. 2014 Journal Article http://hdl.handle.net/20.500.11937/20199 10.6000/1927-7229.2014.03.01.1 Lifescience Global fulltext |
| spellingShingle | β-catenin cellular proliferation Wnt signalling oestradiol sFRP4 Breast cancer growth inhibition McLaren, S. Arfuso, Frank Zeps, N. Dharmarajan, Arunasalam The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line |
| title | The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line |
| title_full | The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line |
| title_fullStr | The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line |
| title_full_unstemmed | The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line |
| title_short | The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line |
| title_sort | role of secreted frizzled related protein 4 (sfrp-4) in regulating oestradiol-induced growth of the mcf-7 breast cancer cell line |
| topic | β-catenin cellular proliferation Wnt signalling oestradiol sFRP4 Breast cancer growth inhibition |
| url | http://hdl.handle.net/20.500.11937/20199 |