Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays
Wnt proteins are often up-regulated in cancer. The secreted frizzled-related proteins (sFRPs) can abrogate Wnt signalling and are involved in apoptosis. We investigated the expression of Wnt1, β-Catenin, and an antagonist, sFRP4, as well as apoptosis in breast cancer using tissue micro-arrays (TMAs)...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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Lifescience Global
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/19312 |
| _version_ | 1848749997394231296 |
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| author | Berry, A. Charles, A. Zeps, N. Cregan, D. Arfuso, Frank Dharmarajan, Arunasalam |
| author_facet | Berry, A. Charles, A. Zeps, N. Cregan, D. Arfuso, Frank Dharmarajan, Arunasalam |
| author_sort | Berry, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Wnt proteins are often up-regulated in cancer. The secreted frizzled-related proteins (sFRPs) can abrogate Wnt signalling and are involved in apoptosis. We investigated the expression of Wnt1, β-Catenin, and an antagonist, sFRP4, as well as apoptosis in breast cancer using tissue micro-arrays (TMAs) comprising 191 tissue cores. Results demonstrated stronger staining intensity for Wnt1 in tumour versus non-tumour samples (p<0.05). Epithelial sFRP4 did not differ between invasive and non-invasive tissue; however, there was increased sFRP4 expression in the blood vessels and lymphocyte cells of tumour compared to non-tumour tissue. These data suggest Wnt involvement in determining the breast cancer phenotype and highlight a potential new role for sFRP4 as a diagnostic/prognostic marker. |
| first_indexed | 2025-11-14T07:29:49Z |
| format | Journal Article |
| id | curtin-20.500.11937-19312 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:29:49Z |
| publishDate | 2014 |
| publisher | Lifescience Global |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-193122017-09-13T13:42:27Z Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays Berry, A. Charles, A. Zeps, N. Cregan, D. Arfuso, Frank Dharmarajan, Arunasalam Wnt secreted frizzled-related protein 4 Breast tissue micro-arrays cancer Wnt proteins are often up-regulated in cancer. The secreted frizzled-related proteins (sFRPs) can abrogate Wnt signalling and are involved in apoptosis. We investigated the expression of Wnt1, β-Catenin, and an antagonist, sFRP4, as well as apoptosis in breast cancer using tissue micro-arrays (TMAs) comprising 191 tissue cores. Results demonstrated stronger staining intensity for Wnt1 in tumour versus non-tumour samples (p<0.05). Epithelial sFRP4 did not differ between invasive and non-invasive tissue; however, there was increased sFRP4 expression in the blood vessels and lymphocyte cells of tumour compared to non-tumour tissue. These data suggest Wnt involvement in determining the breast cancer phenotype and highlight a potential new role for sFRP4 as a diagnostic/prognostic marker. 2014 Journal Article http://hdl.handle.net/20.500.11937/19312 10.6000/1927-7229.2014.03.04.4 Lifescience Global fulltext |
| spellingShingle | Wnt secreted frizzled-related protein 4 Breast tissue micro-arrays cancer Berry, A. Charles, A. Zeps, N. Cregan, D. Arfuso, Frank Dharmarajan, Arunasalam Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays |
| title | Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays |
| title_full | Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays |
| title_fullStr | Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays |
| title_full_unstemmed | Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays |
| title_short | Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays |
| title_sort | expression profile of wnt/β-catenin signalling molecules and the wnt antagonist secreted frizzled-related protein 4 in apoptosis in breast cancer tissue micro-arrays |
| topic | Wnt secreted frizzled-related protein 4 Breast tissue micro-arrays cancer |
| url | http://hdl.handle.net/20.500.11937/19312 |