Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor

The amyloid- (A) peptide is neurotoxic and associated with the pathology of Alzheimer's disease (AD). We investigated the effect of A peptides on insulin binding to the insulin receptor because it is known that (1) A and insulin are both amyloidogenic peptides sharing a common sequence recognit...

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Bibliographic Details
Main Authors: Xie, Ling, Helmerhorst, Erik, Plewright, Brian, Van Bronswijk, Wilhelm, Martins, R.
Format: Journal Article
Published: Society of Neuroscience 2002
Subjects:
insulin binding
Scatchard analysis
diabetes
Alzheimer's disease
insulin receptors
amyloid- peptide
Online Access:http://www.jneurosci.org/content/vol22/issue10/
http://hdl.handle.net/20.500.11937/19003

Internet

http://www.jneurosci.org/content/vol22/issue10/
http://hdl.handle.net/20.500.11937/19003

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