Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell
It is now widely accepted that reactive oxygen species (ROS) contribute to cell and tissue dysfunction and damage in diabetes. The source of ROS in the insulin secreting pancreatic beta cells has traditionally been considered to be the mitochondrial electron transport chain. While this source is und...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
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Springer Verlag
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/18782 |
| _version_ | 1848749844361904128 |
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| author | Newsholme, Philip Morgan, D. Rebelato, E. Oliveira-Emilio, H. Procopio, J. Curi, R. Carpinelli, A. |
| author_facet | Newsholme, Philip Morgan, D. Rebelato, E. Oliveira-Emilio, H. Procopio, J. Curi, R. Carpinelli, A. |
| author_sort | Newsholme, Philip |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | It is now widely accepted that reactive oxygen species (ROS) contribute to cell and tissue dysfunction and damage in diabetes. The source of ROS in the insulin secreting pancreatic beta cells has traditionally been considered to be the mitochondrial electron transport chain. While this source is undoubtedly important, we fully describe in this article recent information and evidence of NADPH oxidase-dependent generation of ROS in pancreatic beta cells and identify the various isoforms that contribute to O 2•- and H2O2 production in various conditions. While glucose-stimulated ROS generation may be important for acute regulation of insulin secretion, at higher levels ROS may disrupt mitochondrial energy metabolism. However, ROS may alter other cellular processes such as signal transduction, ion fluxes and/or cell proliferation/death. The various beta cell isoforms of NADPH oxidase (described in this review) may, via differences in the kinetics and species of ROS generated, positively and negatively regulate insulin secretion and cell survival. © 2009 Springer-Verlag. |
| first_indexed | 2025-11-14T07:27:23Z |
| format | Journal Article |
| id | curtin-20.500.11937-18782 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:27:23Z |
| publishDate | 2009 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-187822017-09-13T13:46:03Z Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell Newsholme, Philip Morgan, D. Rebelato, E. Oliveira-Emilio, H. Procopio, J. Curi, R. Carpinelli, A. It is now widely accepted that reactive oxygen species (ROS) contribute to cell and tissue dysfunction and damage in diabetes. The source of ROS in the insulin secreting pancreatic beta cells has traditionally been considered to be the mitochondrial electron transport chain. While this source is undoubtedly important, we fully describe in this article recent information and evidence of NADPH oxidase-dependent generation of ROS in pancreatic beta cells and identify the various isoforms that contribute to O 2•- and H2O2 production in various conditions. While glucose-stimulated ROS generation may be important for acute regulation of insulin secretion, at higher levels ROS may disrupt mitochondrial energy metabolism. However, ROS may alter other cellular processes such as signal transduction, ion fluxes and/or cell proliferation/death. The various beta cell isoforms of NADPH oxidase (described in this review) may, via differences in the kinetics and species of ROS generated, positively and negatively regulate insulin secretion and cell survival. © 2009 Springer-Verlag. 2009 Journal Article http://hdl.handle.net/20.500.11937/18782 10.1007/s00125-009-1536-z Springer Verlag unknown |
| spellingShingle | Newsholme, Philip Morgan, D. Rebelato, E. Oliveira-Emilio, H. Procopio, J. Curi, R. Carpinelli, A. Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell |
| title | Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell |
| title_full | Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell |
| title_fullStr | Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell |
| title_full_unstemmed | Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell |
| title_short | Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell |
| title_sort | insights into the critical role of nadph oxidase(s) in the normal and dysregulated pancreatic beta cell |
| url | http://hdl.handle.net/20.500.11937/18782 |