A nanoparticulate system that enhances the efficacy of the tumoricide Dz13 when administered proximal to the lesion site

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A nanoparticulate system that enhances the efficacy of the tumoricide Dz13 when administered proximal to the lesion site

We demonstrate that Dz13, a DNA enzyme that cleaves c-Jun mRNA, and is capable of inhibiting cancer cell growth in vitro, can be encapsulated into chitosan nanoparticles. For optimisation of this chitosan-based formulation, pH 6, 0.02% chitosan concentration, and 55 °C were found to be best among th...

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Bibliographic Details
Main Authors:	Tan, M., Dunstan, D., Friedhuber, A., Choong, P., Dass, Crispin
Format:	Journal Article
Published:	Elsevier 2010
Online Access:	http://hdl.handle.net/20.500.11937/18238

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