A nanoparticulate system that enhances the efficacy of the tumoricide Dz13 when administered proximal to the lesion site
We demonstrate that Dz13, a DNA enzyme that cleaves c-Jun mRNA, and is capable of inhibiting cancer cell growth in vitro, can be encapsulated into chitosan nanoparticles. For optimisation of this chitosan-based formulation, pH 6, 0.02% chitosan concentration, and 55 °C were found to be best among th...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Elsevier
2010
|
| Online Access: | http://hdl.handle.net/20.500.11937/18238 |