Bile signalling promotes chronic respiratory infections and antibiotic tolerance

QR Code

Bile signalling promotes chronic respiratory infections and antibiotic tolerance

Despite aggressive antimicrobial therapy, many respiratory pathogens persist in the lung, underpinning the chronic inflammation and eventual lung decline that are characteristic of respiratory disease. Recently, bile acid aspiration has emerged as a major comorbidity associated with a range of lung...

Full description

Bibliographic Details
Main Authors:	Reen, F., Flynn, S., Woods, D., Dunphy, N., Chróinín, M., Mullane, D., Stick, S., Adams, C., O'Gara, Fergal
Format:	Journal Article
Published:	Nature Publishing Group 2016
Online Access:	http://hdl.handle.net/20.500.11937/17382

Similar Items

Translational research for chronic respiratory disease: intercepting the bile aspiration paradigm
by: Reen, F., et al.
Published: (2014)

Intercepting the Bile Aspiration Paradigm: Innovative Intervention for Chronic Respiratory Disease
by: Reen, F., et al.
Published: (2015)

Respiratory Pathogens Adopt a Chronic Lifestyle in Response to Bile
by: Reen, F., et al.
Published: (2012)

Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients
by: Reen, F., et al.
Published: (2014)

Bile Acids Repress Hypoxia-Inducible Factor 1 Signaling and Modulate the Airway Immune Response
by: Legendre, C., et al.
Published: (2014)

Dissecting the regulation of bile-induced biofilm formation in Staphylococcus aureus.
by: Ulluwishewa, D., et al.
Published: (2016)

Bile acids destabilise HIF-1a and promote anti-tumour phenotypes in cancer cell models.
by: Phelan, J., et al.
Published: (2016)

Rethinking the bile acid/gut microbiome axis in cancer
by: Phelan, J., et al.
Published: (2017)

Bile salt chenodeoxycholate suppresses normal platelet functions through cyclic amp activation pathway
by: Metharom, Pat, et al.
Published: (2015)

Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections
by: Ó Muimhneacháin, E., et al.
Published: (2018)

Mining Microbial Signals for Enhanced Biodiscovery of Secondary Metabolites
by: Reen, F., et al.
Published: (2017)

The Microbiome of an Active Meat Curing Brine
by: Woods, D., et al.
Published: (2019)

The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes
by: Reen, F., et al.
Published: (2018)

Harnessing Marine Biocatalytic Reservoirs for Green Chemistry Applications through Metagenomic Technologies
by: Castilla, I., et al.
Published: (2018)

Harnessing bacterial signals for suppression of biofilm formation in the nosocomial fungal pathogen aspergillus fumigatus
by: Reen, F.J., et al.
Published: (2016)

The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa
by: Shanahan, R., et al.
Published: (2017)

Subinhibitory concentrations of the cationic antimicrobial peptide colistin induce the pseudomonas quinolone signal in Pseudomonas aeruginosa
by: Cummins, J., et al.
Published: (2009)

Is there potential for repurposing statins as novel antimicrobials?
by: Hennessy, E., et al.
Published: (2016)

Pseudomonas aeruginosa Alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1a degradation
by: Legendre, C., et al.
Published: (2012)

The impact of phytochemicals present in the diet on microbial signalling in the human gut
by: McCarthy, R., et al.
Published: (2015)

Acid and bile tolerance of Lactobacillus isolated from chicken intestine
by: Jin, Li Zhi, et al.
Published: (1998)

Implications of interspecies signaling for virulence of bacterial and fungal pathogens
by: Holcombe, L., et al.
Published: (2011)

Low oxygen induces the type III secretion system in Pseudomonas aeruginosa via modulation of the small RNAs rsmZ and rsmY
by: O'Callaghan, J., et al.
Published: (2011)

A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus
by: Reen, F., et al.
Published: (2015)

Tle distribution and diversity in metagenomic datasets reveal niche specialization
by: Egan, F., et al.
Published: (2015)

Simultaneous chemosensing of tryptophan and the bacterial signal molecule indole by boron doped diamond electrode
by: Buzid, A., et al.
Published: (2018)

Rapid Electrochemical Detection of Pseudomonas aeruginosa Signaling Molecules by Boron-Doped Diamond Electrode
by: Buzid, A., et al.
Published: (2018)

Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans
by: McAlester, G., et al.
Published: (2008)

The sound of silence: Activating silent biosynthetic gene clusters in marine microorganisms
by: Reen, F., et al.
Published: (2015)

Antibiotic selection leads to inadvertent selection of nfxC-type phenotypic mutants in Pseudomonas aeruginosa
by: Mooij, M., et al.
Published: (2010)

Disruption of N-acyl-homoserine lactone-specific signalling and virulence in clinical pathogens by marine sponge bacteria
by: Gutiérrez-Barranquero, J., et al.
Published: (2018)

Emerging concepts promising new horizons for marine biodiscovery and synthetic biology
by: Reen, F., et al.
Published: (2015)

Analysis of pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode
by: Zhou, L., et al.
Published: (2012)

A non-classical LysR-type transcriptional regulator PA2206 is required for an effective oxidative stress response in Pseudomonas aeruginosa.
by: Reen, F, et al.
Published: (2013)

The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour
by: Reen, F., et al.
Published: (2011)

Synthesis of 3-halo-analogues of HHQ, subsequent cross-coupling and first crystal structure of Pseudomonas quinolone signal (PQS)
by: McGlacken, G., et al.
Published: (2010)

Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode
by: Zhou, L., et al.
Published: (2011)

A novel host-responsive sensor mediates virulence and type III secretion during Pseudomonas aeruginosa-host cell interactions
by: O'Callaghan, J., et al.
Published: (2012)

One step preparation and electrochemical analysis of IQS, a cell–cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa
by: Shang, F., et al.
Published: (2014)

CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa
by: Tian, Z., et al.
Published: (2016)