Inhibition of OCTN2-mediated transport of carnitine by etoposide

QR Code

Inhibition of OCTN2-mediated transport of carnitine by etoposide

OCTN2 is a bifunctional transporter that reabsorbs filtered carnitine in a sodium-dependent manner andsecretes organic cations into urine as a proton antiport mechanism. We hypothesized that inhibition of OCTN2 by anticancer drugs can influence carnitine resorption. OCTN2-mediated transport inhibiti...

Full description

Bibliographic Details
Main Authors:	Hu, C., Lancaster, C., Zuo, Zhili, Hu, S., Chen, Z., Rubnitz, J., Baker, S., Sparreboom, A.
Format:	Journal Article
Published:	American Association for Cancer Research 2013
Online Access:	http://hdl.handle.net/20.500.11937/15970

Similar Items

Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine Wasting
by: Lancaster, C., et al.
Published: (2010)

Understanding the roles and impact of Solute Carrier Transporters OCT1, OCTN1, and OCTN2 in lung epithelia
by: Magana Gomez, Paulyna Gabriela
Published: (2024)

Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men
by: Shannon, Chris E., et al.
Published: (2016)

Skeletal muscle carnitine metabolism during intense exercise in human volunteers
by: Shannon, C.E.
Published: (2016)

Hexokinase and carnitine palmitoyltransferase activities in flight muscles of grasshopper Valanga nigricornis(burm.)
by: Lee, C. W., et al.
Published: (1983)

Etoposide-induced apoptosis results in chromosome breaks within the AF9 gene: Its implication in chromosome rearrangement in leukaemia
by: Cynthia Patricia, Nicholas, et al.
Published: (2012)

Molecular Dynamics Simulations on the Mechanism of Transporting Methylamine and Ammonia by Ammonium Transporter AmtB
by: Wang, J., et al.
Published: (2010)

Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent
by: Porter, Craig, et al.
Published: (2017)

Effect of L-carnitine intake on exercise performance among athletes: a scoping review
by: Mariadas, Matiusdas S/O
Published: (2021)

Modulation of muscle fuel metabolism in human volunteers by increasing the availability of muscle acetyl-CoA and carnitine moieties
by: Ghasemi, Reza
Published: (2016)

Antibacterial Activities of Carbapenem Derivatives and Quantitative Structure - Activity Relationship for Drug Design
by: Liu, J., et al.
Published: (2008)

Community safety for public transportation during Covid-19 pandemic / Huipeng Hu
by: Huipeng, Hu
Published: (2022)

Blood inflammatory markers, anabolic hormone, vitamin D and L-carnitine status according to frailty status among older adults
by: Manal Badrasawi,, et al.
Published: (2019)

Structural insight into tanapoxvirus‐mediated inhibition of apoptosis
by: Suraweera, Chathura D., et al.
Published: (2020)

Molecular docking and structure-activity relationship studies on benzothiazole based non-peptidic BACE-1 inhibitors
by: Xu, W., et al.
Published: (2010)

Identification of a sub-micromolar, non-peptide inhibitor of β-secretase with low neural cytotoxicity through in silico screening
by: Xu, W., et al.
Published: (2010)

A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma: a final report
by: Gnekow, Astrid K., et al.
Published: (2017)

Calculations of the free energy of interaction of the cFos-cJun coiled coil: effects of the solvation model and the inclusion of polarization effects
by: Zuo, Zhili, et al.
Published: (2010)

Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans
by: Stephens, Francis B., et al.
Published: (2013)

Molecular Docking and 3-D QSAR Studies of Substituted 2,2-Bisaryl-Bicycloheptanes as Human 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors
by: Ma, X., et al.
Published: (2008)

ARID3B silencing inhibits E2F-mediated transcription and cell proliferation
by: A. S. M. Saadat, Khandakar, et al.
Published: (2013)

Inhibition of the lysophosphatidylinositol transporter abcc1 reduces prostate cancer cell growth and sensitizes to chemotherapy
by: Emmanouilidi, Aikaterini, et al.
Published: (2020)

The observation on the inhibition of anti-inflammatory mediator of the tomato leaves extract
by: Amid, Azura, et al.
Published: (2011)

A CO2-tolerant nanostructured layer for oxygen transport membranes
by: Zhang, Z., et al.
Published: (2014)

Efficacy and tolerability of a sunscreen containing licochalcone A and L-carnitine as an adjunct to retinoids in the management of acne and post-acne pigmentation among Malaysian patients
by: How, Kang Nien, et al.
Published: (2023)

Experimental investigation and modelling of wax deposition inhibition in pipeline transportation of crude oil
by: Norida, Ridzuan
Published: (2016)

A Study of the Relationship between Human Resource Practices and Turnover Intention among Chinese Millennial Employees, with Mediation of Job Embeddedness
by: Hu, Xinyu
Published: (2022)

Mitigating Dissent: A Grounded Formal Theory of Two Hidden Routines from Corporate Social Irresponsibility to Corporate Social Responsibility
by: Chen, Zhili
Published: (2013)

Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters
by: Samms, Ricardo J., et al.
Published: (2015)

Free Energy Calculations of the Interactions of c-Jun-based Synthetic Peptides with the c-Fos Protein
by: Zuo, Zhili, et al.
Published: (2012)

Is technology-mediated learning made equal for all? Examining the influences of gender and learning style
by: Hu, P., et al.
Published: (2011)

2, 4, 6,-trihydroxy- 3-geranylacetophenone (tHGA) inhibits newly synthesized mediators release in IgE-mediated mast cell degranulation
by: Tan, Ji Wei, et al.
Published: (2015)

Data of Effects of Combined L-Carnitine Supplementation and Moderateintensity Exercise on Body Composition, Metabolic and Oxidative Stress Markers, Bone Parameters and Muscular Performance in Overweight and Obese Individuals
by: Ahmad, Nur Syamsina
Published: (2022)

Effects of combined l-carnitine supplementation and moderate-intensity exercise on body composition, metabolic and oxidative stress markers, bone parameters and muscular performance in overweight and obese individuals
by: Samsudin, Norsuriani
Published: (2023)

Examining the role of learning engagement in technology-mediated learning and its effects on learning effectiveness and satisfaction
by: Hu, P., et al.
Published: (2012)

RANK-Fc inhibits malignancy via inhibiting ERK activation and evoking caspase-3-mediated anoikis in human osteosarcoma cells
by: Akiyama, T., et al.
Published: (2010)

A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition
by: Zachariou, Margarita, et al.
Published: (2013)

Inhibition of P-glycoprotein - Mediated Efflux of Digoxinand Its Metabolites by Macrolide Antibiotics
by: Hughes, Jeffery, et al.
Published: (2010)

The antimalarial effect of curcumin is mediated by the inhibition of glycogen synthase kinase-3β
by: Ali, Amatul Hamizah, et al.
Published: (2017)

Novel non-peptide β-secretase inhibitors derived from structure-based virtual screening and bioassay
by: Xu, W., et al.
Published: (2009)

Cannot write session to /tmp/vufind_sessions/sess_1t4lcqm7d7s8o5gjptb8bti2pk