An investigation of p53’s differential activation of cell cycle arrest and apoptosis

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An investigation of p53’s differential activation of cell cycle arrest and apoptosis

The p53 tumour suppressor protein lies at the hub of a very complex network of cellular pathways including apoptosis, cell cycle arrest, DNA repair and cellular senescence. However, the mechanism of why and how p53 switches between apoptosis and cell cycle arrest, thereby determining a cell’s fate,...

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Bibliographic Details
Main Author:	Zhang, Yuan
Format:	Thesis
Language:	English
Published:	Curtin University 2008
Subjects:	apoptosis nutlin-3 p53 tumour suppressor protein cisplatin cell cycle arrest differential activation
Online Access:	http://hdl.handle.net/20.500.11937/1577

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