Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects

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Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects

A new craze! A new chemical scaffold, namely a staurosporine-like molecule (shown) possessing a pyrazolone core, was found to be highly selective for glycogen synthase kinase 3 over a group of other homologous kinases, including typical cyclin-dependent kinases. This compound gave an impressive dose...

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Bibliographic Details
Main Authors:	Chen, W., Gaisina, I., Gunosewoyo, Hendra, Malekiani, S., Hanania, T., Kozikowski, A.
Format:	Journal Article
Published:	Wiley-VCH Verlag GmbH & Co. KGaA 2011
Subjects:	kinase selectivity mania GSK-3 neuroprotection bipolar disorders
Online Access:	http://hdl.handle.net/20.500.11937/15540

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