Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects

Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects

A new craze! A new chemical scaffold, namely a staurosporine-like molecule (shown) possessing a pyrazolone core, was found to be highly selective for glycogen synthase kinase 3 over a group of other homologous kinases, including typical cyclin-dependent kinases. This compound gave an impressive dose...

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Bibliographic Details
Main Authors: Chen, W., Gaisina, I., Gunosewoyo, Hendra, Malekiani, S., Hanania, T., Kozikowski, A.
Format: Journal Article
Published: Wiley-VCH Verlag GmbH & Co. KGaA 2011
Subjects:
kinase selectivity
mania
GSK-3
neuroprotection
bipolar disorders
Online Access:http://hdl.handle.net/20.500.11937/15540

Internet

http://hdl.handle.net/20.500.11937/15540

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