Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects
A new craze! A new chemical scaffold, namely a staurosporine-like molecule (shown) possessing a pyrazolone core, was found to be highly selective for glycogen synthase kinase 3 over a group of other homologous kinases, including typical cyclin-dependent kinases. This compound gave an impressive dose...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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Wiley-VCH Verlag GmbH & Co. KGaA
2011
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/15540 |
| _version_ | 1848748920525553664 |
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| author | Chen, W. Gaisina, I. Gunosewoyo, Hendra Malekiani, S. Hanania, T. Kozikowski, A. |
| author_facet | Chen, W. Gaisina, I. Gunosewoyo, Hendra Malekiani, S. Hanania, T. Kozikowski, A. |
| author_sort | Chen, W. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | A new craze! A new chemical scaffold, namely a staurosporine-like molecule (shown) possessing a pyrazolone core, was found to be highly selective for glycogen synthase kinase 3 over a group of other homologous kinases, including typical cyclin-dependent kinases. This compound gave an impressive dose–response curve for neuroprotection in the homocysteic acid model of oxidative stress (graph shown), and furthermore, blocked chemically induced mania-like effects in mice. |
| first_indexed | 2025-11-14T07:12:42Z |
| format | Journal Article |
| id | curtin-20.500.11937-15540 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:12:42Z |
| publishDate | 2011 |
| publisher | Wiley-VCH Verlag GmbH & Co. KGaA |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-155402018-03-29T09:07:21Z Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects Chen, W. Gaisina, I. Gunosewoyo, Hendra Malekiani, S. Hanania, T. Kozikowski, A. kinase selectivity mania GSK-3 neuroprotection bipolar disorders A new craze! A new chemical scaffold, namely a staurosporine-like molecule (shown) possessing a pyrazolone core, was found to be highly selective for glycogen synthase kinase 3 over a group of other homologous kinases, including typical cyclin-dependent kinases. This compound gave an impressive dose–response curve for neuroprotection in the homocysteic acid model of oxidative stress (graph shown), and furthermore, blocked chemically induced mania-like effects in mice. 2011 Journal Article http://hdl.handle.net/20.500.11937/15540 10.1002/cmdc.201100231 Wiley-VCH Verlag GmbH & Co. KGaA restricted |
| spellingShingle | kinase selectivity mania GSK-3 neuroprotection bipolar disorders Chen, W. Gaisina, I. Gunosewoyo, Hendra Malekiani, S. Hanania, T. Kozikowski, A. Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects |
| title | Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects |
| title_full | Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects |
| title_fullStr | Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects |
| title_full_unstemmed | Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects |
| title_short | Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects |
| title_sort | structure-guided design of a highly selective glycogen synthase kinase-3ß inhibitor: a superior neuroprotective pyrazolone showing antimania effects |
| topic | kinase selectivity mania GSK-3 neuroprotection bipolar disorders |
| url | http://hdl.handle.net/20.500.11937/15540 |