The role of the sFRP4 protein in modulation of cancer growth and anti-neoplastic drug sensitivity
This project found that reintroducing a regulatory protein, sFRP4, to mesothelioma cancer cell models could inhibit their growth, ability to migrate and induce a form of cell death. In addition sFRP4 could sensitise mesothelioma cells to drug treatment. The mechanisms involved were studied in detai...
| Main Author: | |
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| Format: | Thesis |
| Language: | English |
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Curtin University
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/1548 |
| _version_ | 1848743698202886144 |
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| author | Perumal, Vanathi |
| author_facet | Perumal, Vanathi |
| author_sort | Perumal, Vanathi |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This project found that reintroducing a regulatory protein, sFRP4, to mesothelioma cancer cell models could inhibit their growth, ability to migrate and induce a form of cell death. In addition sFRP4 could sensitise mesothelioma cells to drug treatment. The mechanisms involved were studied in detail and the project provided new insights into the functions of this protein including identifying the protein structures involved in these effects and its role in cancer cells. |
| first_indexed | 2025-11-14T05:49:42Z |
| format | Thesis |
| id | curtin-20.500.11937-1548 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T05:49:42Z |
| publishDate | 2014 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-15482018-06-05T02:35:55Z The role of the sFRP4 protein in modulation of cancer growth and anti-neoplastic drug sensitivity Perumal, Vanathi This project found that reintroducing a regulatory protein, sFRP4, to mesothelioma cancer cell models could inhibit their growth, ability to migrate and induce a form of cell death. In addition sFRP4 could sensitise mesothelioma cells to drug treatment. The mechanisms involved were studied in detail and the project provided new insights into the functions of this protein including identifying the protein structures involved in these effects and its role in cancer cells. 2014 Thesis http://hdl.handle.net/20.500.11937/1548 en Curtin University fulltext |
| spellingShingle | Perumal, Vanathi The role of the sFRP4 protein in modulation of cancer growth and anti-neoplastic drug sensitivity |
| title | The role of the sFRP4 protein in modulation of cancer growth and anti-neoplastic drug sensitivity |
| title_full | The role of the sFRP4 protein in modulation of cancer growth and anti-neoplastic drug sensitivity |
| title_fullStr | The role of the sFRP4 protein in modulation of cancer growth and anti-neoplastic drug sensitivity |
| title_full_unstemmed | The role of the sFRP4 protein in modulation of cancer growth and anti-neoplastic drug sensitivity |
| title_short | The role of the sFRP4 protein in modulation of cancer growth and anti-neoplastic drug sensitivity |
| title_sort | role of the sfrp4 protein in modulation of cancer growth and anti-neoplastic drug sensitivity |
| url | http://hdl.handle.net/20.500.11937/1548 |