Mathematical Model of Metabolism and Electrophysiology of Amino Acid and Glucose Stimulated Insulin Secretion: In Vitro Validation Using a β-Cell Line

QR Code

Mathematical Model of Metabolism and Electrophysiology of Amino Acid and Glucose Stimulated Insulin Secretion: In Vitro Validation Using a β-Cell Line

We integrated biological experimental data with mathematical modelling to gain insights into the role played by L-alanine in amino acid-stimulated insulin secretion (AASIS) and in D-glucose-stimulated insulin secretion (GSIS), details important to the understanding of complex β-cell metabolic coupli...

Full description

Bibliographic Details
Main Authors:	Salvucci, Manuela, Neufeld, Zoltan, Newsholme, Philip
Format:	Journal Article
Published:	Public Library of Science 2013
Online Access:	http://hdl.handle.net/20.500.11937/14659

Similar Items

Mathematical model of glucose and amino acid induced toxicity in pancreatic beta cells
by: Salvucci, M., et al.
Published: (2012)

Metabolic Regulation of Insulin Secretion
by: Keane, Kevin, et al.
Published: (2014)

β-cell metabolism, insulin production and secretion: Metabolic failure resulting in diabetes
by: Chen, Y., et al.
Published: (2016)

Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal ß-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism
by: Bender, K., et al.
Published: (2009)

Nutritional Regulation of Insulin Secretion: Implications for Diabetes
by: Newsholme, Philip, et al.
Published: (2012)

Nutrient regulation of insulin secretion and action
by: Newsholme, Philip, et al.
Published: (2014)

(Dys)Regulation of Insulin Secretion by Macronutrients
by: Newsholme, Philip, et al.
Published: (2015)

Effect of the antipsychotic agent amisulpride on glucose lowering and insulin secretion
by: Roix, J., et al.
Published: (2012)

Amino Acid Metabolism
by: Newsholme, Philip, et al.
Published: (2011)

Nutrient regulation of insulin secretion and ß-cell functional integrity
by: Newsholme, Philip, et al.
Published: (2010)

Melatonin modifies basal and stimulated insulin secretion via NADPH oxidase
by: Simões, D., et al.
Published: (2016)

Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using intensive control insulin-nutrition-glucose model
by: Jamaludin, Ummu Kulthum, et al.
Published: (2017)

Carnosine scavenging of glucolipotoxic free radicals enhances insulin secretion and glucose uptake.
by: Cripps, M.J., et al.
Published: (2017)

Angiotensin II receptor blocker valsartan enhances glucose-induced insulin secretion
by: Ayob, Azizi, et al.
Published: (2006)

Postprandial changes in glucose oxidation and insulin sensitivity in metabolic syndrome: Influence of fibroblast growth factor 21 and vitamin D status
by: Pathak, K., et al.
Published: (2017)

Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic ß-cells
by: McClenaghan, N., et al.
Published: (2009)

Effect of ficus deltoidea extracts on hepatic basal and insulin-stimulated glucose uptake
by: Adam, Z., et al.
Published: (2009)

Pluchea indica extracts stimulates insulin secretion through enhancement of Irs2 and Glut2 genes expression in RIN-5F pancreatic β-cells
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2014)

Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic ß-cells
by: Keane, D., et al.
Published: (2008)

The effects of cannabinoids on insulin secretion
by: Anderson, Richard L.
Published: (2011)

Hydrogen peroxide stimulates glucose uptake in myotube cells via the insulin signaling pathway
by: Musalmah Mazlan,, et al.
Published: (2010)

Insulin secreted from genetically engineered intestinal cells reduces blood glucose levels in diabetic mice
by: Rasouli, Mina, et al.
Published: (2013)

Lupin seed hydrolysate promotes G-protein-coupled receptor, intracellular Ca2+ and enhanced glycolytic metabolism-mediated insulin secretion from BRIN-BD11 pancreatic beta cells
by: Tapadia, M., et al.
Published: (2018)

Regulation of cancer stem cell metabolism by secreted frizzled-related protein 4 (SFRP4)
by: Deshmukh, Abhijeet, et al.
Published: (2018)

GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation
by: Carlessi, Rodrigo, et al.
Published: (2017)

Pigment epithelium-derived factor (PEDF) regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line BRIN-BD11 and mouse islets
by: Chen, Y., et al.
Published: (2016)

Size-related assessment on viability and insulin secretion of caprine islets in vitro
by: Vakhshiteh, Faezeh, et al.
Published: (2013)

Cytotoxicity and cytoprotective effects of citrus flavonoids on insulin-secreting cells BRIN-BD11: beneficial synergic effects.
by: Felipe, E., et al.
Published: (2013)

Amino acids and diabetes: implications for endocrine, metabolic and immune function
by: Newsholme, Philip, et al.
Published: (2011)

Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 ß-cell insulin secretion and signal transduction
by: Kiely, A., et al.
Published: (2009)

The Role of Amyloidogenic Peptides in Disruption of Insulin Secretion and Action
by: Rowles, Joanne Elizabeth
Published: (2023)

The effects of insulin resistance on individual tissues: an application of a mathematical model of metabolism in humans
by: Pearson, Taliesin, et al.
Published: (2016)

Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis
by: Zachariou, Margarita, et al.
Published: (2008)

Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids
by: Newsholme, Philip, et al.
Published: (2012)

Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using ICING model
by: Jamaludin, Ummu Kulthum, et al.
Published: (2016)

Estimation of Plasma Insulin and Endogenous Insulin Secretion in Critically Ill Patients Using ICING Model
by: Ummu Kulthum, Jamaludin, et al.
Published: (2017)

Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta-cell KATP channels and stimulate insulin secretion: statins as a test case
by: Real, Joana, et al.
Published: (2018)

Short-chain fatty acids: possible regulators of insulin secretion
by: Rosli, Nur Suraya Ashikin, et al.
Published: (2022)

Hypoglycemic activity of Curculigo latifolia on insulin and glucose uptake activities in in vitro
by: Ishak, Nur Akmal, et al.
Published: (2019)

Amino acid modulation of gut hormone release and defining roles of GLP-1 and insulin in muscle microcirculation and metabolism in older age
by: Abdulla, Haitham M.A.
Published: (2018)

Cannot write session to /tmp/vufind_sessions/sess_k03n723jges2sf2q76f9j41p3v