The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid
The biogenesis and accumulation of the beta amyloid protein (Aß) is a key event in the cascade of oxidative and inflammatory processes that characterises Alzheimer’s disease. The presenilins and its interacting proteins play a pivotal role in the generation of Aß from the amyloid precursor protein (...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
Kluwer Academic Publishers-Plenum Publishers
2007
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| Online Access: | http://hdl.handle.net/20.500.11937/14145 |
| _version_ | 1848748543329697792 |
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| author | Verdile, Giuseppe Gandy, S. Martins, R. |
| author_facet | Verdile, Giuseppe Gandy, S. Martins, R. |
| author_sort | Verdile, Giuseppe |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The biogenesis and accumulation of the beta amyloid protein (Aß) is a key event in the cascade of oxidative and inflammatory processes that characterises Alzheimer’s disease. The presenilins and its interacting proteins play a pivotal role in the generation of Aß from the amyloid precursor protein (APP). In particular, three proteins (nicastrin, aph-1 and pen-2) interact with presenilins to form a large multi-subunit enzymatic complex (?-secretase) that cleaves APP to generate Aß. Reconstitution studies in yeast and insect cells have provided strong evidence that these four proteins are the major components of the ?-secretase enzyme. Current research is directed at elucidating the roles that each of these protein play in the function of this enzyme. In addition, a number of presenilin interacting proteins that are not components of ?-secretase play important roles in modulating Aß production. This review will discuss the components of the ?-secretase complex and the role of presenilin interacting proteins on ?-secretase activity. |
| first_indexed | 2025-11-14T07:06:43Z |
| format | Journal Article |
| id | curtin-20.500.11937-14145 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:06:43Z |
| publishDate | 2007 |
| publisher | Kluwer Academic Publishers-Plenum Publishers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-141452017-09-13T15:02:44Z The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid Verdile, Giuseppe Gandy, S. Martins, R. The biogenesis and accumulation of the beta amyloid protein (Aß) is a key event in the cascade of oxidative and inflammatory processes that characterises Alzheimer’s disease. The presenilins and its interacting proteins play a pivotal role in the generation of Aß from the amyloid precursor protein (APP). In particular, three proteins (nicastrin, aph-1 and pen-2) interact with presenilins to form a large multi-subunit enzymatic complex (?-secretase) that cleaves APP to generate Aß. Reconstitution studies in yeast and insect cells have provided strong evidence that these four proteins are the major components of the ?-secretase enzyme. Current research is directed at elucidating the roles that each of these protein play in the function of this enzyme. In addition, a number of presenilin interacting proteins that are not components of ?-secretase play important roles in modulating Aß production. This review will discuss the components of the ?-secretase complex and the role of presenilin interacting proteins on ?-secretase activity. 2007 Journal Article http://hdl.handle.net/20.500.11937/14145 10.1007/s11064-006-9131-x Kluwer Academic Publishers-Plenum Publishers unknown |
| spellingShingle | Verdile, Giuseppe Gandy, S. Martins, R. The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid |
| title | The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid |
| title_full | The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid |
| title_fullStr | The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid |
| title_full_unstemmed | The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid |
| title_short | The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid |
| title_sort | role of presenilin and its interacting proteins in the biogenesis of alzheimer’s beta amyloid |
| url | http://hdl.handle.net/20.500.11937/14145 |