Formation of assemblies on cell membranes by secreted proteins: molecular studies of free ? light chain aggregates found on the surface of myeloma cells

Formation of assemblies on cell membranes by secreted proteins: molecular studies of free ? light chain aggregates found on the surface of myeloma cells

We have described the presence of cell-membrane-associated ?FLCs (free immunoglobulin light chains) on the surface of myeloma cells. Notably, the anti-?FLC mAb (monoclonal antibody) MDX-1097 is being assessed in clinical trials as a therapy for ? light chain isotype multiple myeloma. Despite the cli...

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Bibliographic Details
Main Authors: Hutchinson, A., Malik, A., Berkahn, M., Agostino, Mark, To, J., Tacchi, J., Djordjevic, S., Turnbull, L., Whitchurch, C., Edmundson, A., Jones, D., Raison, R., Ramsland, Paul
Format: Journal Article
Published: Portland Press Ltd. 2013
Online Access:http://hdl.handle.net/20.500.11937/13910

Internet

http://hdl.handle.net/20.500.11937/13910

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