Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents
The cyclocondensations of 3,4-dihydroquinazolin-2-yl guanidine with a variety of electrophilic reagents viz. aldehydes, ketones, triethyl orthoformate, diethyl ethoxymethylenemalonate, carbon disulfide and trichloroacetonitrile were found to afford 1,3,5-triazino[2,1-b]quinazolines. However, some un...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
The Japan Institute of Heterocyclic Chemistry
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/13442 |
| _version_ | 1848748348597600256 |
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| author | Dolzhenko, Anton Foo, M. Tan, B. Dolzhenko, A. Chiu, G. Chui, W. |
| author_facet | Dolzhenko, Anton Foo, M. Tan, B. Dolzhenko, A. Chiu, G. Chui, W. |
| author_sort | Dolzhenko, Anton |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The cyclocondensations of 3,4-dihydroquinazolin-2-yl guanidine with a variety of electrophilic reagents viz. aldehydes, ketones, triethyl orthoformate, diethyl ethoxymethylenemalonate, carbon disulfide and trichloroacetonitrile were found to afford 1,3,5-triazino[2,1-b]quinazolines. However, some unexpected reactions were also observed. The structural properties such as tautomerism and hinderance to conformational rotation were also investigated. The results of biological testing suggested that the 1,3,5-triazino[2,1-b]quinazoline nucleus could be a new promising scaffold for the development of potential anticancer agents. |
| first_indexed | 2025-11-14T07:03:37Z |
| format | Journal Article |
| id | curtin-20.500.11937-13442 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:03:37Z |
| publishDate | 2009 |
| publisher | The Japan Institute of Heterocyclic Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-134422017-01-30T11:37:10Z Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents Dolzhenko, Anton Foo, M. Tan, B. Dolzhenko, A. Chiu, G. Chui, W. The cyclocondensations of 3,4-dihydroquinazolin-2-yl guanidine with a variety of electrophilic reagents viz. aldehydes, ketones, triethyl orthoformate, diethyl ethoxymethylenemalonate, carbon disulfide and trichloroacetonitrile were found to afford 1,3,5-triazino[2,1-b]quinazolines. However, some unexpected reactions were also observed. The structural properties such as tautomerism and hinderance to conformational rotation were also investigated. The results of biological testing suggested that the 1,3,5-triazino[2,1-b]quinazoline nucleus could be a new promising scaffold for the development of potential anticancer agents. 2009 Journal Article http://hdl.handle.net/20.500.11937/13442 The Japan Institute of Heterocyclic Chemistry fulltext |
| spellingShingle | Dolzhenko, Anton Foo, M. Tan, B. Dolzhenko, A. Chiu, G. Chui, W. Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents |
| title | Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents |
| title_full | Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents |
| title_fullStr | Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents |
| title_full_unstemmed | Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents |
| title_short | Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents |
| title_sort | synthesis and heterocyclizations of 3,4-dihydroquinazolin-2-yl guanidine in the search of new anticancer agents |
| url | http://hdl.handle.net/20.500.11937/13442 |