The Effect of Nonsense Mediated Decay on Transcriptional Activity Within the Novel ß-Thalassemia Mutation HBB: c.129delT

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The Effect of Nonsense Mediated Decay on Transcriptional Activity Within the Novel ß-Thalassemia Mutation HBB: c.129delT

Premature termination codons (PTCs) are caused by mutations in the coding sequences of functional genes resulting in an incorrect assignment of a stop codon. Abnormal and truncated proteins are prevented from being translated due to the rapid degradation of mRNA carrying these mutations by an RNA su...

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Bibliographic Details
Main Authors:	Forster, L., Ardakani, R., Qadah, T., Finlayson, J., Ghassemifar, Reza
Format:	Journal Article
Published:	Taylor and Francis Ltd 2015
Online Access:	http://hdl.handle.net/20.500.11937/13258

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