The Effect of Nonsense Mediated Decay on Transcriptional Activity Within the Novel ß-Thalassemia Mutation HBB: c.129delT
Premature termination codons (PTCs) are caused by mutations in the coding sequences of functional genes resulting in an incorrect assignment of a stop codon. Abnormal and truncated proteins are prevented from being translated due to the rapid degradation of mRNA carrying these mutations by an RNA su...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Taylor and Francis Ltd
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/13258 |