Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine Wasting

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Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine Wasting

Purpose: Carnitine is an essential cofactor for mitochondrial fatty acid oxidation that is actively reabsorbed by the luminal transporter Octn2 (Slc22a5). Because the nephrotoxic agent cisplatin causes urinary loss of carnitine in humans, we hypothesized that cisplatin may affect Octn2 function. Exp...

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Bibliographic Details
Main Authors:	Lancaster, C., Hu, C., Franke, R., Filipski, K., Orwick, S., Zhaoyuan, C., Zuo, Zhili, Loos, W., Sparreboom, A.
Format:	Journal Article
Published:	American Association Cancer Research 2010
Online Access:	http://hdl.handle.net/20.500.11937/12846

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