Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine Wasting
Purpose: Carnitine is an essential cofactor for mitochondrial fatty acid oxidation that is actively reabsorbed by the luminal transporter Octn2 (Slc22a5). Because the nephrotoxic agent cisplatin causes urinary loss of carnitine in humans, we hypothesized that cisplatin may affect Octn2 function. Exp...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
American Association Cancer Research
2010
|
| Online Access: | http://hdl.handle.net/20.500.11937/12846 |