Pigment epithelium-derived factor upregulates collagen I and downregulates matrix metalloproteinase 2 in osteosarcoma cells, and colocalises to collagen I and heat shock protein 47 in fetal and adult bone

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Pigment epithelium-derived factor upregulates collagen I and downregulates matrix metalloproteinase 2 in osteosarcoma cells, and colocalises to collagen I and heat shock protein 47 in fetal and adult bone

Objective: Pigment epithelium-derived factor (PEDF) has proven anti-osteosarcoma activity. However, the mechanism(s) underpinning its ability to reduce primary bone tumour (osteosarcoma) metastasis is unknown. Methods: Adult and fetal murine bone were immunostained for PEDF, collagen I (major protei...

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Bibliographic Details
Main Authors:	Alcantara, M., Nemazannikova, N., Elahy, M., Dass, Crispin
Format:	Journal Article
Published:	John Wiley & Sons Ltd. 2014
Subjects:	pigment epithelium-derived factor bone collagen I matrix metalloproteinase cancer
Online Access:	http://hdl.handle.net/20.500.11937/11650

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