Pigment epithelium-derived factor upregulates collagen I and downregulates matrix metalloproteinase 2 in osteosarcoma cells, and colocalises to collagen I and heat shock protein 47 in fetal and adult bone
Objective: Pigment epithelium-derived factor (PEDF) has proven anti-osteosarcoma activity. However, the mechanism(s) underpinning its ability to reduce primary bone tumour (osteosarcoma) metastasis is unknown. Methods: Adult and fetal murine bone were immunostained for PEDF, collagen I (major protei...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
John Wiley & Sons Ltd.
2014
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/11650 |