Albumin fusion prolongs the antioxidant and anti-inflammatory activities of thioredoxin in mice with acetaminophen-induced hepatitis

Albumin fusion prolongs the antioxidant and anti-inflammatory activities of thioredoxin in mice with acetaminophen-induced hepatitis

Overdoses of acetaminophen (APAP) are a major cause of acute liver failure. N-acetylcysteine (NAC) is the standard therapy for the patients with such an overdose because oxidative stress plays an important role in the pathogenesis of APAP-induced hepatitis. However, NAC is not sufficiently efficacio...

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Bibliographic Details
Main Authors: Tanaka, R., Ishima, Y., Maeda, H., Kodama, A., Nagao, S., Watanabe, H., Chuang, Victor, Otagiri, M., Maruyama, T.
Format: Journal Article
Published: American Chemical Society 2014
Subjects:
recombinant protein
inflammation
acetaminophen
drug delivery system
oxidative stress
Online Access:http://hdl.handle.net/20.500.11937/11402

Internet

http://hdl.handle.net/20.500.11937/11402

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