Comparison of single high-dose streptozotocin with partial pancreatectomy combined with low-dose streptozotocin for diabetes induction in rhesus monkeys

Comparison of single high-dose streptozotocin with partial pancreatectomy combined with low-dose streptozotocin for diabetes induction in rhesus monkeys

Monkeys with insulin-dependent diabetes are important experimental models for islet xenotransplantation. However, with regard to diabetes induction, total pancreatectomy is a difficult operation with a high complication rate, while streptozotocin (STZ) administration may cause serious toxic effects...

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Bibliographic Details
Main Authors: Jin, X., Zeng, L., He, S., Chen, Younan, Tian, B., Mai, G., Yang, G., Wei, L., Zhang, Y., Li, H., Wang, L., Qiao, C., Cheng, J., Lu, Y.
Format: Journal Article
Published: SAGE Publications Inc. 2010
Online Access:http://hdl.handle.net/20.500.11937/10843

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