Regioselective synthesis of pyrimido [1,2-a][1,3,5]triazin-6-ones via reaction of 1-(6-oxo-1,6-dihydropyrimidin-2-yl)guanidines with triethylorthoacetate: Observation of an unexpected rearrangement

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Regioselective synthesis of pyrimido [1,2-a][1,3,5]triazin-6-ones via reaction of 1-(6-oxo-1,6-dihydropyrimidin-2-yl)guanidines with triethylorthoacetate: Observation of an unexpected rearrangement

A novel thermal rearrangement, involving pyrimidine ring opening and subsequent ring closure leading to recyclization of the system, was identified in the reaction of (6-oxo-1,6- dihydropyrimidin-2-yl)guanidines 3 (where NR1R2 = NH2, NH alkyl, NH aralkyl, NHCH2Ph(R)) with triethyl orthoacetate, affo...

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Bibliographic Details
Main Authors:	Sachdeva, N., Dolzhenko, Anton, Chui, W.
Format:	Journal Article
Published:	The Royal Society of Chemistry 2012
Subjects:	3 X-ray crystal structure triazines 2-a][1 guanidines pyrimido[1 5]triazines rearrangement pyrimidines
Online Access:	http://hdl.handle.net/20.500.11937/10305

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