Regioselective synthesis of pyrimido [1,2-a][1,3,5]triazin-6-ones via reaction of 1-(6-oxo-1,6-dihydropyrimidin-2-yl)guanidines with triethylorthoacetate: Observation of an unexpected rearrangement
A novel thermal rearrangement, involving pyrimidine ring opening and subsequent ring closure leading to recyclization of the system, was identified in the reaction of (6-oxo-1,6- dihydropyrimidin-2-yl)guanidines 3 (where NR1R2 = NH2, NH alkyl, NH aralkyl, NHCH2Ph(R)) with triethyl orthoacetate, affo...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
The Royal Society of Chemistry
2012
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/10305 |