Multi-bifurcation flow analysis on 2D human respiratory airway system
Drug inhalation through respiratory airway is the principal method in attaining therapeutic effect for many lung diseases. The multi-bifurcating flow structure acquires deep understanding on the flow driven transportation. This work employs Navier-Stokes equation with Splitting Method numerical flow...
| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Published: |
2010
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| Subjects: | |
| Online Access: | http://eprints.uthm.edu.my/1632/ http://eprints.uthm.edu.my/1632/1/Zamani_FKMP_(CSSR2010).pdf |
| Summary: | Drug inhalation through respiratory airway is the
principal method in attaining therapeutic effect for many lung
diseases. The multi-bifurcating flow structure acquires deep
understanding on the flow driven transportation. This work
employs Navier-Stokes equation with Splitting Method
numerical flow solver utilizing domain characterization
technique. Various breathing conditions are commenced to
Weibel’s morphometric lung model from fifth to seventh
generations of human respiratory system. Velocity
distributions, vortex formations and cross-sectional velocity
profiles are considered for Reynolds number ranging from
resting to moderate exercise breathing. Flow with low
Reynolds number retains its symmetric cross-sectional velocity
profile across each bifurcation region while higher Reynolds
number shows the other way. Drug delivery efficacy is higher
with slower inhalation while hard breathing stimulates vortex
formations and disturbs drug distributions right through the
multi-bifurcation structure. |
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