Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity
Stenochlaena palustris fronds are popular as a vegetable in Southeast Asia. The objectives of this study were to evaluate the anticholinesterase properties and phytochemical profiles of the young and mature fronds of this plant. Both types of fronds were found to have selective inhibitory effect...
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Elsevier
2016
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| Online Access: | https://doi.org/10.1016/j.jfda.2015.12.005 https://doi.org/10.1016/j.jfda.2015.12.005 |
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usm-38444 |
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eprints |
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usm-384442018-01-19T07:38:29Z Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity Chear, Nelson Jeng Yeou Khaw, Kooi Yeong Murugaiyah, Vikneswaran Lai, Choon Sheen RM300-666 Drugs and their actions RS1-441 Pharmacy and materia medica Stenochlaena palustris fronds are popular as a vegetable in Southeast Asia. The objectives of this study were to evaluate the anticholinesterase properties and phytochemical profiles of the young and mature fronds of this plant. Both types of fronds were found to have selective inhibitory effect against butyrylcholinesterase compared with acetylcholinesterase. However, different sets of compounds were responsible for their activity. In young fronds, an antibutyrylcholinesterase effect was observed in the hexane extract, which was comprised of a variety of aliphatic hydrocarbons, fatty acids, and phytosterols. In the mature fronds, inhibitory activity was observed in the methanol extract, which contained a series of kaempferol glycosides. Our results provided novel information concerning the ability of S. palustris to inhibit cholinesterase and its phytochemical profile. Further research to investigate the potential use of this plant against Alzheimer's disease is warranted, however, young and mature fronds should be distinguished due to their phytochemical differences. Elsevier 2016-04 Article PeerReviewed https://doi.org/10.1016/j.jfda.2015.12.005 Chear, Nelson Jeng Yeou and Khaw, Kooi Yeong and Murugaiyah, Vikneswaran and Lai, Choon Sheen (2016) Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity. Journal of Food and Drug Analysis, 24 (2). pp. 358-366. ISSN 1021-9498 http://eprints.usm.my/38444/ |
| institution |
Universiti Sains Malaysia Universiti Sains Malaysia |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| building |
USM Repository |
| collection |
Online Access |
| topic |
RM300-666 Drugs and their actions RS1-441 Pharmacy and materia medica |
| spellingShingle |
RM300-666 Drugs and their actions RS1-441 Pharmacy and materia medica Chear, Nelson Jeng Yeou Khaw, Kooi Yeong Murugaiyah, Vikneswaran Lai, Choon Sheen Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity |
| description |
Stenochlaena palustris fronds are popular as a vegetable in Southeast Asia. The objectives of
this study were to evaluate the anticholinesterase properties and phytochemical profiles of
the young and mature fronds of this plant. Both types of fronds were found to have selective
inhibitory effect against butyrylcholinesterase compared with acetylcholinesterase.
However, different sets of compounds were responsible for their activity. In young fronds,
an antibutyrylcholinesterase effect was observed in the hexane extract, which was
comprised of a variety of aliphatic hydrocarbons, fatty acids, and phytosterols. In the
mature fronds, inhibitory activity was observed in the methanol extract, which contained a
series of kaempferol glycosides. Our results provided novel information concerning the
ability of S. palustris to inhibit cholinesterase and its phytochemical profile. Further
research to investigate the potential use of this plant against Alzheimer's disease is warranted,
however, young and mature fronds should be distinguished due to their phytochemical differences. |
| format |
Article |
| author |
Chear, Nelson Jeng Yeou Khaw, Kooi Yeong Murugaiyah, Vikneswaran Lai, Choon Sheen |
| author_facet |
Chear, Nelson Jeng Yeou Khaw, Kooi Yeong Murugaiyah, Vikneswaran Lai, Choon Sheen |
| author_sort |
Chear, Nelson Jeng Yeou |
| title |
Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity |
| title_short |
Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity |
| title_full |
Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity |
| title_fullStr |
Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity |
| title_full_unstemmed |
Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity |
| title_sort |
cholinesterase inhibitory activity and chemical constituents of stenochlaena palustris fronds at two different stages of maturity |
| publisher |
Elsevier |
| publishDate |
2016 |
| url |
https://doi.org/10.1016/j.jfda.2015.12.005 https://doi.org/10.1016/j.jfda.2015.12.005 |
| first_indexed |
2018-09-08T09:28:40Z |
| last_indexed |
2018-09-08T09:28:40Z |
| _version_ |
1611031034766295040 |